[HTML][HTML] Genetic studies of Crohn's disease: past, present and future
JZ Liu, CA Anderson - Best Practice & Research Clinical Gastroenterology, 2014 - Elsevier
The exact aetiology of Crohn's disease is unknown, though it is clear from early
epidemiological studies that a combination of genetic and environmental risk factors
contributes to an individual's disease susceptibility. Here, we review the history of gene-
mapping studies of Crohn's disease, from the linkage-based studies that first implicated the
NOD2 locus, through to modern-day genome-wide association studies that have discovered
over 140 loci associated with Crohn's disease and yielded novel insights into the biological …
epidemiological studies that a combination of genetic and environmental risk factors
contributes to an individual's disease susceptibility. Here, we review the history of gene-
mapping studies of Crohn's disease, from the linkage-based studies that first implicated the
NOD2 locus, through to modern-day genome-wide association studies that have discovered
over 140 loci associated with Crohn's disease and yielded novel insights into the biological …