STAT3-mediated constitutive expression of SOCS3 in an undifferentiated rat trophoblast-like cell line
A Isobe, T Takeda, M Sakata, T Yamamoto… - Placenta, 2006 - Elsevier
In the trophoblast, constitutive expression of SOCS3 is important for the negative regulation
of trophoblast giant cell differentiation. In this study, we analyzed the signaling pathway
regulating the constitutive SOCS3 expression in undifferentiated Rcho-1 cells, which were
derived from rat choriocarcinoma and consist of trophoblast stem cells that are capable of
differentiating to trophoblast giant cells in vitro. PD98059, an MEK inhibitor, repressed the
SOCS3 expression but AG490, a JAK2 inhibitor, did not. Promoter deletion analysis …
of trophoblast giant cell differentiation. In this study, we analyzed the signaling pathway
regulating the constitutive SOCS3 expression in undifferentiated Rcho-1 cells, which were
derived from rat choriocarcinoma and consist of trophoblast stem cells that are capable of
differentiating to trophoblast giant cells in vitro. PD98059, an MEK inhibitor, repressed the
SOCS3 expression but AG490, a JAK2 inhibitor, did not. Promoter deletion analysis …