[HTML][HTML] Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice
M Yamazaki, T Pearson, MA Brehm, DM Miller… - American Journal of …, 2007 - Elsevier
Regulatory T cells (Treg) are important in peripheral tolerance, but their role in establishing
and maintaining hematopoietic mixed chimerism and generating central tolerance is
unclear. We now show that costimulation blockade using a donor-specific transfusion and
anti-CD154 antibody applied to mice given bone marrow and simultaneously transplanted
with skin allografts leads to hematopoietic chimerism and permanent skin allograft survival.
Chimeric mice bearing intact skin allografts fail to generate effector/memory T cells against …
and maintaining hematopoietic mixed chimerism and generating central tolerance is
unclear. We now show that costimulation blockade using a donor-specific transfusion and
anti-CD154 antibody applied to mice given bone marrow and simultaneously transplanted
with skin allografts leads to hematopoietic chimerism and permanent skin allograft survival.
Chimeric mice bearing intact skin allografts fail to generate effector/memory T cells against …