Class switch recombination: a comparison between mouse and human
Q Pan‐Hammarström, Y Zhao, L Hammarström - Advances in immunology, 2007 - Elsevier
Humans and mice separated more than 60 million years ago. Since then, evolution has led
to a multitude of changes in their genomic sequences. The divergence of genes has resulted
in differences both in the innate and adaptive immune systems. In this chapter, we focus on
species difference with regard to immunoglobulin class switch recombination (CSR). We
have compared the immunoglobulin constant region gene loci from human and mouse, with
an emphasis on the switch regions, germ line transcription promoters, and 3′ enhancers …
to a multitude of changes in their genomic sequences. The divergence of genes has resulted
in differences both in the innate and adaptive immune systems. In this chapter, we focus on
species difference with regard to immunoglobulin class switch recombination (CSR). We
have compared the immunoglobulin constant region gene loci from human and mouse, with
an emphasis on the switch regions, germ line transcription promoters, and 3′ enhancers …