[HTML][HTML] Splenic marginal zone antigen‐presenting cells are critical for the primary allo‐immune response to therapeutic factor VIII in hemophilia A
A Navarrete, S Dasgupta, S Delignat, G Caligiuri… - Journal of Thrombosis …, 2009 - Elsevier
Background: Alloimmune responses to intravenously administered protein therapeutics are
the most common cause of failure of replacement therapy in patients with defective levels of
endogenous proteins. Such a situation is encountered in some patients with hemophilia A,
who develop inhibitory anti‐factor (F) VIII alloantibodies after administration of FVIII to treat
hemorrhages. Objectives: The nature of the secondary lymphoid organs involved in the
initiation of immune responses to human therapeutic has not been studied. We therefore …
the most common cause of failure of replacement therapy in patients with defective levels of
endogenous proteins. Such a situation is encountered in some patients with hemophilia A,
who develop inhibitory anti‐factor (F) VIII alloantibodies after administration of FVIII to treat
hemorrhages. Objectives: The nature of the secondary lymphoid organs involved in the
initiation of immune responses to human therapeutic has not been studied. We therefore …