Uptake of blood coagulation factor VIII by dendritic cells is mediated via its C1 domain
BACKGROUND: The uptake and processing of blood coagulation factor VIII (FVIII) by
antigen-presenting cells and the subsequent presentation of FVIII-derived peptides to CD4+
T cells direct the immune response to FVIII in patients with hemophilia A. Multiple receptors
including mannose receptor and low-density lipoprotein receptor–related protein-1 (LRP1)
have been implicated in FVIII uptake. OBJECTIVE: This work studies the involvement of
receptor candidates in FVIII uptake by dendritic cells (DCs). Furthermore, we explore FVIII …
antigen-presenting cells and the subsequent presentation of FVIII-derived peptides to CD4+
T cells direct the immune response to FVIII in patients with hemophilia A. Multiple receptors
including mannose receptor and low-density lipoprotein receptor–related protein-1 (LRP1)
have been implicated in FVIII uptake. OBJECTIVE: This work studies the involvement of
receptor candidates in FVIII uptake by dendritic cells (DCs). Furthermore, we explore FVIII …