[PDF][PDF] The dynamics of apoptotic cell clearance

MR Elliott, KS Ravichandran - Developmental cell, 2016 - cell.com
Developmental cell, 2016cell.com
The phagocytic clearance of dying cells in a tissue is a highly orchestrated series of
intercellular events coordinated by a complex signaling network. Recent data from genetic,
biochemical, and live-imaging approaches have greatly enhanced our understanding of the
dynamics of cell clearance and how the process is orchestrated at the cellular and tissue
levels. We discuss how networks regulating apoptotic cell clearance are integrated to
enable a rapid, efficient, and high-capacity clearance system within tissues.
The phagocytic clearance of dying cells in a tissue is a highly orchestrated series of intercellular events coordinated by a complex signaling network. Recent data from genetic, biochemical, and live-imaging approaches have greatly enhanced our understanding of the dynamics of cell clearance and how the process is orchestrated at the cellular and tissue levels. We discuss how networks regulating apoptotic cell clearance are integrated to enable a rapid, efficient, and high-capacity clearance system within tissues.
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