Intracellular protein O-GlcNAc modification integrates nutrient status with transcriptional and metabolic regulation
AK Nagel, LE Ball - Advances in cancer research, 2015 - Elsevier
The inducible, nutrient-sensitive posttranslational modification of protein Ser/Thr residues
with O-linked β-N-acetylglucosamine (O-GlcNAc) occurs on histones, transcriptional
regulators, metabolic enzymes, oncogenes, tumor suppressors, and many critical
intermediates of growth factor signaling. Cycling of O-GlcNAc modification on and off of
protein substrates is catalyzed by the actions of O-GlcNAc transferase (OGT) and O-
GlcNAcase (OGA), respectively. To date, there are less than 150 publications addressing the …
with O-linked β-N-acetylglucosamine (O-GlcNAc) occurs on histones, transcriptional
regulators, metabolic enzymes, oncogenes, tumor suppressors, and many critical
intermediates of growth factor signaling. Cycling of O-GlcNAc modification on and off of
protein substrates is catalyzed by the actions of O-GlcNAc transferase (OGT) and O-
GlcNAcase (OGA), respectively. To date, there are less than 150 publications addressing the …