Reduction of immunocompetent T cells followed by prolonged lymphopenia in severe sepsis in the elderly
S Inoue, K Suzuki-Utsunomiya, Y Okada… - Critical care …, 2013 - journals.lww.com
Objective: To investigate the immunological changes caused by severe sepsis in elderly
patients. Design: One-year, prospective observational study. Setting: Emergency department
and intensive care unit of a single university hospital. Patients: Seventy-three patients with
severe sepsis and 72 healthy donors. Measurements and Main Results: In elderly septic
patients (aged 65 yr and over), 3-month survival was significantly reduced compared with
that for adult patients (18–64 yr)(60% vs. 89%, p< 0.01). We found that lymphopenia was …
patients. Design: One-year, prospective observational study. Setting: Emergency department
and intensive care unit of a single university hospital. Patients: Seventy-three patients with
severe sepsis and 72 healthy donors. Measurements and Main Results: In elderly septic
patients (aged 65 yr and over), 3-month survival was significantly reduced compared with
that for adult patients (18–64 yr)(60% vs. 89%, p< 0.01). We found that lymphopenia was …