The contribution of cytotoxic and noncytotoxic function by donor T-cells that support engraftment after allogeneic bone marrow transplantation
Z Jiang, GB Adams, AM Hanash… - Biology of blood and …, 2002 - tctjournal.org
The present studies were designed for investigation of the requirements for cytotoxic
function in donor T-cells transplanted to support engraftment after infusion of allogeneic
bone marrow. The experiments examined the capacity of donor CD8+ T-cells lacking Fas
ligand and/or perforin function to facilitate donor B6 congenic (B6-Ly5. 1) BM engraftment
across major histocompatibility complex class I/II barriers after transplantation. T-cell-
depleted BM cells from B6-Ly5. 1 donors were transplanted into sublethally irradiated (5.5 …
function in donor T-cells transplanted to support engraftment after infusion of allogeneic
bone marrow. The experiments examined the capacity of donor CD8+ T-cells lacking Fas
ligand and/or perforin function to facilitate donor B6 congenic (B6-Ly5. 1) BM engraftment
across major histocompatibility complex class I/II barriers after transplantation. T-cell-
depleted BM cells from B6-Ly5. 1 donors were transplanted into sublethally irradiated (5.5 …