Outcomes after allogeneic hematopoietic cell transplantation for childhood cerebral adrenoleukodystrophy: the largest single-institution cohort report

WP Miller, SM Rothman, D Nascene… - Blood, The Journal …, 2011 - ashpublications.org
WP Miller, SM Rothman, D Nascene, T Kivisto, TE DeFor, RS Ziegler, J Eisengart, K Leiser…
Blood, The Journal of the American Society of Hematology, 2011ashpublications.org
Cerebral adrenoleukodystrophy (cALD) remains a devastating neurodegenerative disease;
only allogeneic hematopoietic cell transplantation (HCT) has been shown to provide long-
term disease stabilization and survival. Sixty boys undergoing HCT for cALD from 2000 to
2009 were analyzed. The median age at HCT was 8.7 years; conditioning regimens and
allograft sources varied. At HCT, 50% demonstrated a Loes radiographic severity score≥
10, and 62% showed clinical evidence of neurologic dysfunction. A total of 78%(n= 47) are …
Abstract
Cerebral adrenoleukodystrophy (cALD) remains a devastating neurodegenerative disease; only allogeneic hematopoietic cell transplantation (HCT) has been shown to provide long-term disease stabilization and survival. Sixty boys undergoing HCT for cALD from 2000 to 2009 were analyzed. The median age at HCT was 8.7 years; conditioning regimens and allograft sources varied. At HCT, 50% demonstrated a Loes radiographic severity score ≥ 10, and 62% showed clinical evidence of neurologic dysfunction. A total of 78% (n = 47) are alive at a median 3.7 years after HCT. The estimate of 5-year survival for boys with Loes score < 10 at HCT was 89%, whereas that for boys with Loes score ≥ 10 was 60% (P = .03). The 5-year survival estimate for boys absent of clinical cerebral disease at HCT was 91%, whereas that for boys with neurologic dysfunction was 66% (P = .08). The cumulative incidence of transplantation-related mortality at day 100 was 8%. Post-transplantation progression of neurologic dysfunction depended significantly on the pre-HCT Loes score and clinical neurologic status. We describe the largest single-institution analysis of survival and neurologic function outcomes after HCT in cALD. These trials were registered at www.clinicaltrials.gov as #NCT00176904, #NCT00668564, and #NCT00383448.
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