[HTML][HTML] Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function
IR Watson, A Blanch, DCC Lin, M Ohh… - Journal of biological …, 2006 - ASBMB
Mutations in p73 are rare in cancer. Emerging evidence suggests that the relative
expression of various p73 isoforms may contribute to tumorigenesis. Alternative promoters
and N-terminal splicing result in the transcription and processing of either full-length (TA) or
N-terminally truncated (ΔN) p73 isoforms. TAp73 possesses pro-apoptotic functions, while
ΔNp73 has anti-apoptotic properties via functional inhibition of TAp73 and p53. Here, we
report that TAp73, but not ΔNp73, is covalently modified by NEDD8 under physiologic …
expression of various p73 isoforms may contribute to tumorigenesis. Alternative promoters
and N-terminal splicing result in the transcription and processing of either full-length (TA) or
N-terminally truncated (ΔN) p73 isoforms. TAp73 possesses pro-apoptotic functions, while
ΔNp73 has anti-apoptotic properties via functional inhibition of TAp73 and p53. Here, we
report that TAp73, but not ΔNp73, is covalently modified by NEDD8 under physiologic …