[HTML][HTML] Docosahexaenoic acid modifies the clustering and size of lipid rafts and the lateral organization and surface expression of MHC class I of EL4 cells
SR Shaikh, BD Rockett, K Carraway - The Journal of nutrition, 2009 - Elsevier
An emerging molecular mechanism by which docosahexaenoic acid (DHA) exerts its effects
is modification of lipid raft organization. The biophysical model, based on studies with
liposomes, shows that DHA avoids lipid rafts because of steric incompatibility between DHA
and cholesterol. The model predicts that DHA does not directly modify rafts; rather, it
incorporates into nonrafts to modify the lateral organization and/or conformation of
membrane proteins, such as the major histocompatibility complex (MHC) class I. Here, we …
is modification of lipid raft organization. The biophysical model, based on studies with
liposomes, shows that DHA avoids lipid rafts because of steric incompatibility between DHA
and cholesterol. The model predicts that DHA does not directly modify rafts; rather, it
incorporates into nonrafts to modify the lateral organization and/or conformation of
membrane proteins, such as the major histocompatibility complex (MHC) class I. Here, we …