Activation of YAP attenuates hepatic damage and fibrosis in liver ischemia-reperfusion injury
Y Liu, T Lu, C Zhang, J Xu, Z Xue, RW Busuttil, N Xu… - Journal of …, 2019 - Elsevier
Background & Aims Hepatic ischemia-reperfusion injury (IRI) is a major complication of
hemorrhagic shock, liver resection and transplantation. YAP, a key downstream effector of
the Hippo pathway, is essential for determining cell fate and maintaining homeostasis in the
liver. We aimed to elucidate its role in IRI. Methods The role of YAP/Hippo signaling was
systematically studied in biopsy specimens from 60 patients after orthotopic liver
transplantation (OLT), and in a mouse model of liver warm IRI. Human biopsy specimens …
hemorrhagic shock, liver resection and transplantation. YAP, a key downstream effector of
the Hippo pathway, is essential for determining cell fate and maintaining homeostasis in the
liver. We aimed to elucidate its role in IRI. Methods The role of YAP/Hippo signaling was
systematically studied in biopsy specimens from 60 patients after orthotopic liver
transplantation (OLT), and in a mouse model of liver warm IRI. Human biopsy specimens …