Endoplasmic reticulum protein quality control in β cells
N Shrestha, RB Reinert, L Qi - Seminars in cell & developmental biology, 2020 - Elsevier
N Shrestha, RB Reinert, L Qi
Seminars in cell & developmental biology, 2020•ElsevierType 1 and type 2 diabetes are associated with loss of β cell function. Optimal β cell function
is linked to protein homeostasis in the endoplasmic reticulum (ER). Here, we review the
roles of ER protein quality-control mechanisms, including the unfolded protein response
(UPR), autophagy (specifically ER-phagy) and ER-associated degradation (ERAD), in β
cells. We propose that different quality control mechanisms may control different aspects of β
cell biology (ie function, survival, and identity), thereby contributing to disease pathogenesis.
is linked to protein homeostasis in the endoplasmic reticulum (ER). Here, we review the
roles of ER protein quality-control mechanisms, including the unfolded protein response
(UPR), autophagy (specifically ER-phagy) and ER-associated degradation (ERAD), in β
cells. We propose that different quality control mechanisms may control different aspects of β
cell biology (ie function, survival, and identity), thereby contributing to disease pathogenesis.
Abstract
Type 1 and type 2 diabetes are associated with loss of β cell function. Optimal β cell function is linked to protein homeostasis in the endoplasmic reticulum (ER). Here, we review the roles of ER protein quality-control mechanisms, including the unfolded protein response (UPR), autophagy (specifically ER-phagy) and ER-associated degradation (ERAD), in β cells. We propose that different quality control mechanisms may control different aspects of β cell biology (i.e. function, survival, and identity), thereby contributing to disease pathogenesis.
Elsevier