IL-10 receptor signaling empowers regulatory T cells to control Th17 responses and protect from GN
P Diefenhardt, A Nosko, MA Kluger… - Journal of the …, 2018 - journals.lww.com
Background Th17 cells are central pathogenic mediators of autoimmune disease, including
many forms of GN. IL-10 receptor signaling (IL-10R) in regulatory T cells (Tregs) has been
implicated in the downregulation of Th17 cells, but the underlying molecular mechanisms
and functional relevance of this process remain unclear. Methods We generated mice with
Treg-specific IL-10Ra deficiency and subjected these mice to nephrotoxic serum–induced
nephritis as a model of crescentic GN. Immune responses and Treg phenotypes were …
many forms of GN. IL-10 receptor signaling (IL-10R) in regulatory T cells (Tregs) has been
implicated in the downregulation of Th17 cells, but the underlying molecular mechanisms
and functional relevance of this process remain unclear. Methods We generated mice with
Treg-specific IL-10Ra deficiency and subjected these mice to nephrotoxic serum–induced
nephritis as a model of crescentic GN. Immune responses and Treg phenotypes were …