[PDF][PDF] Dendritic cells require T cells for functional maturation in vivo
V Shreedhar, AM Moodycliffe, SE Ullrich, C Bucana… - Immunity, 1999 - cell.com
V Shreedhar, AM Moodycliffe, SE Ullrich, C Bucana, ML Kripke, L Flores-Romo
Immunity, 1999•cell.comWe examined dendritic cell (DC) status in SCID and RAG2−/− mice to assess the influence
of T cells on DC development and function in vivo. These mice have reduced numbers of DC
in the epidermis and lymph nodes draining hapten-sensitized skin. Epidermal DC in these
mice were defective in presenting antigen in vivo to adoptively transferred, hapten-
sensitized T cells from normal mice. Likewise, draining lymph node DC were deficient in
their capacity to stimulate naive T cells in vitro and in vivo. DC numbers as well as the …
of T cells on DC development and function in vivo. These mice have reduced numbers of DC
in the epidermis and lymph nodes draining hapten-sensitized skin. Epidermal DC in these
mice were defective in presenting antigen in vivo to adoptively transferred, hapten-
sensitized T cells from normal mice. Likewise, draining lymph node DC were deficient in
their capacity to stimulate naive T cells in vitro and in vivo. DC numbers as well as the …
Abstract
We examined dendritic cell (DC) status in SCID and RAG2−/− mice to assess the influence of T cells on DC development and function in vivo. These mice have reduced numbers of DC in the epidermis and lymph nodes draining hapten-sensitized skin. Epidermal DC in these mice were defective in presenting antigen in vivo to adoptively transferred, hapten-sensitized T cells from normal mice. Likewise, draining lymph node DC were deficient in their capacity to stimulate naive T cells in vitro and in vivo. DC numbers as well as the impaired ability to present antigen in vivo, were corrected by reconstituting these animals with normal T lymphocytes, suggesting that T cells are crucial for normal DC maturation and function in vivo.
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