CCR5-Δ32 heterozygosity, HIV-1 reservoir size, and lymphocyte activation in individuals receiving long-term suppressive antiretroviral therapy
The Journal of Infectious Diseases, 2016•academic.oup.com
We conducted a case-controlled study of the associations of CCR5-Δ32 heterozygosity with
human immunodeficiency virus type 1 (HIV-1) reservoir size, lymphocyte activation, and
CCR5 expression in 114 CCR5Δ32/WT and 177 wild-type CCR5 AIDS Clinical Trials Group
participants receiving suppressive antiretroviral therapy. Overall, no significant differences
were found between groups for any of these parameters. However, higher levels of CCR5
expression correlated with lower amounts of cell-associated HIV-1 RNA. The relationship …
human immunodeficiency virus type 1 (HIV-1) reservoir size, lymphocyte activation, and
CCR5 expression in 114 CCR5Δ32/WT and 177 wild-type CCR5 AIDS Clinical Trials Group
participants receiving suppressive antiretroviral therapy. Overall, no significant differences
were found between groups for any of these parameters. However, higher levels of CCR5
expression correlated with lower amounts of cell-associated HIV-1 RNA. The relationship …
Abstract
We conducted a case-controlled study of the associations of CCR5-Δ32 heterozygosity with human immunodeficiency virus type 1 (HIV-1) reservoir size, lymphocyte activation, and CCR5 expression in 114 CCR5Δ32/WT and 177 wild-type CCR5 AIDS Clinical Trials Group participants receiving suppressive antiretroviral therapy. Overall, no significant differences were found between groups for any of these parameters. However, higher levels of CCR5 expression correlated with lower amounts of cell-associated HIV-1 RNA. The relationship between CCR5-Δ32 heterozygosity, CCR5 expression, and markers of HIV-1 persistence is likely to be complex and may be influenced by factors such as the duration of ART.
Oxford University Press