Regulation of cell polarity by PAR-1/MARK kinase
Y Wu, EE Griffin - Current topics in developmental biology, 2017 - Elsevier
PAR-1/MARK kinases are conserved serine/threonine kinases that are essential regulators
of cell polarity. PAR-1/MARK kinases localize and function in opposition to the anterior PAR
proteins to control the asymmetric distribution of factors in a wide variety polarized cells. In
this review, we discuss the mechanisms that control the localization and activity of PAR-
1/MARK kinases, including their antagonistic interactions with the anterior PAR proteins. We
focus on the role PAR-1 plays in the asymmetric division of the Caenorhabditis elegans …
of cell polarity. PAR-1/MARK kinases localize and function in opposition to the anterior PAR
proteins to control the asymmetric distribution of factors in a wide variety polarized cells. In
this review, we discuss the mechanisms that control the localization and activity of PAR-
1/MARK kinases, including their antagonistic interactions with the anterior PAR proteins. We
focus on the role PAR-1 plays in the asymmetric division of the Caenorhabditis elegans …