Transcriptional programming of tissue-resident memory CD8+ T cells
JJ Milner, AW Goldrath - Current opinion in immunology, 2018 - Elsevier
Current opinion in immunology, 2018•Elsevier
Highlights•T RM formation relies on a 'hybrid'program of effector and memory T cell
TFs.•Differentiating T RM are transcriptionally distinct from circulating MP cells.•Blimp1,
Hobit, and Runx3 are central regulators of immune cell tissue-residency.•Therapeutic
manipulation of tissue-residency can be leveraged to treat disease.Tissue-resident memory
CD8+ T cells (T RM) are localized in non-lymphoid tissues throughout the body where they
mediate long-lived protective immunity at common sites of pathogen exposure. As the …
TFs.•Differentiating T RM are transcriptionally distinct from circulating MP cells.•Blimp1,
Hobit, and Runx3 are central regulators of immune cell tissue-residency.•Therapeutic
manipulation of tissue-residency can be leveraged to treat disease.Tissue-resident memory
CD8+ T cells (T RM) are localized in non-lymphoid tissues throughout the body where they
mediate long-lived protective immunity at common sites of pathogen exposure. As the …
Highlights
- T RM formation relies on a ‘hybrid’program of effector and memory T cell TFs.
- Differentiating T RM are transcriptionally distinct from circulating MP cells.
- Blimp1, Hobit, and Runx3 are central regulators of immune cell tissue-residency.
- Therapeutic manipulation of tissue-residency can be leveraged to treat disease.
Tissue-resident memory CD8+ T cells (T RM) are localized in non-lymphoid tissues throughout the body where they mediate long-lived protective immunity at common sites of pathogen exposure. As the signals controlling T RM differentiation are uncovered, it is becoming apparent that the dynamic activities of numerous transcription factors are intricately involved in T RM formation. Here, we highlight known transcriptional regulators of T RM differentiation and discuss how understanding the transcriptional programming of CD8+ T cell residency in non-lymphoid tissues can be leveraged to prevent or treat disease.
Elsevier