Loss of UCP2 impairs cold-induced non-shivering thermogenesis by promoting a shift toward glucose utilization in brown adipose tissue
Abstract Uncoupling protein 2 (UCP2) was discovered in 1997 and classified as an
uncoupling protein largely based on its homology of sequence with UCP1. Since its
discovery, the uncoupling function of UCP2 has been questioned and there is yet no
consensus on the true function of this protein. UCP2 was first proposed to be a reactive
oxygen species (ROS) regulator and an insulin secretion modulator. More recently, it was
demonstrated as a regulator of the mitochondrial fatty acid oxidation, which prompted us to …
uncoupling protein largely based on its homology of sequence with UCP1. Since its
discovery, the uncoupling function of UCP2 has been questioned and there is yet no
consensus on the true function of this protein. UCP2 was first proposed to be a reactive
oxygen species (ROS) regulator and an insulin secretion modulator. More recently, it was
demonstrated as a regulator of the mitochondrial fatty acid oxidation, which prompted us to …