[HTML][HTML] An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase [S]
Fatty acid amide hydrolase (FAAH) regulates amidated lipid transmitters, including the
endocannabinoid anandamide and its N-acyl ethanolamine (NAE) congeners and transient
receptor potential channel agonists N-acyl taurines (NATs). Using both the FAAH inhibitor
PF-3845 and FAAH (−/−) mice, we present a global analysis of changes in NAE and NAT
metabolism caused by FAAH disruption in central and peripheral tissues. Elevations in
anandamide (and other NAEs) were tissue dependent, with the most dramatic changes …
endocannabinoid anandamide and its N-acyl ethanolamine (NAE) congeners and transient
receptor potential channel agonists N-acyl taurines (NATs). Using both the FAAH inhibitor
PF-3845 and FAAH (−/−) mice, we present a global analysis of changes in NAE and NAT
metabolism caused by FAAH disruption in central and peripheral tissues. Elevations in
anandamide (and other NAEs) were tissue dependent, with the most dramatic changes …