Effect of local radiotherapy for bone pain on urinary markers of osteoclast activity
PJ Hoskin, MRL Stratford, LK Folkes, J Regan… - The Lancet, 2000 - thelancet.com
PJ Hoskin, MRL Stratford, LK Folkes, J Regan, JR Yarnold
The Lancet, 2000•thelancet.comUrinary markers of bone resorption, pyridinoline and deoxypyridinoline were measured
before and at 4 weeks after radiotherapy for metastatic bone pain. An association was
shown between relief of metastatic skeletal pain by radiotherapy and low marker
concentrations before and after treatment, lending support to the hypothesis that relief of
metastatic bone pain by radiotherapy relates to an effect on bone, rather than tumour
physiology.
before and at 4 weeks after radiotherapy for metastatic bone pain. An association was
shown between relief of metastatic skeletal pain by radiotherapy and low marker
concentrations before and after treatment, lending support to the hypothesis that relief of
metastatic bone pain by radiotherapy relates to an effect on bone, rather than tumour
physiology.
Urinary markers of bone resorption, pyridinoline and deoxypyridinoline were measured before and at 4 weeks after radiotherapy for metastatic bone pain. An association was shown between relief of metastatic skeletal pain by radiotherapy and low marker concentrations before and after treatment, lending support to the hypothesis that relief of metastatic bone pain by radiotherapy relates to an effect on bone, rather than tumour physiology.
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