[HTML][HTML] Transforming growth factor-β stimulates parathyroid hormone-related protein and osteolytic metastases via Smad and mitogen-activated protein kinase …
SM Käkönen, KS Selander, JM Chirgwin… - Journal of Biological …, 2002 - ASBMB
Transforming growth factor (TGF)-β promotes breast cancer metastasis to bone. To
determine whether the osteolytic factor parathyroid hormone-related protein (PTHrP) is the
primary mediator of the tumor response to TGF-β, mice were inoculated with MDA-MB-231
breast cancer cells expressing a constitutively active TGF-β type I receptor. Treatment of the
mice with a PTHrP-neutralizing antibody greatly decreased osteolytic bone metastases.
There were fewer osteoclasts and significantly decreased tumor area in the antibody-treated …
determine whether the osteolytic factor parathyroid hormone-related protein (PTHrP) is the
primary mediator of the tumor response to TGF-β, mice were inoculated with MDA-MB-231
breast cancer cells expressing a constitutively active TGF-β type I receptor. Treatment of the
mice with a PTHrP-neutralizing antibody greatly decreased osteolytic bone metastases.
There were fewer osteoclasts and significantly decreased tumor area in the antibody-treated …