Ionizing radiation promotes migration and invasion of cancer cells through transforming growth factor-beta–mediated epithelial–mesenchymal transition
YC Zhou, JY Liu, J Li, J Zhang, YQ Xu… - International Journal of …, 2011 - Elsevier
PURPOSE: To examine whether ionizing radiation enhances the migratory and invasive
abilities of cancer cells through transforming growth factor (TGF-β)–mediated epithelial–
mesenchymal transition (EMT). METHODS AND MATERIALS: Six cancer cell lines
originating from different human organs were irradiated by 60Co γ-ray at a total dose of 2
Gy, and the changes associated with EMT, including morphology, EMT markers, migration
and invasion, were observed by microscope, Western blot, immunofluorescence, scratch …
abilities of cancer cells through transforming growth factor (TGF-β)–mediated epithelial–
mesenchymal transition (EMT). METHODS AND MATERIALS: Six cancer cell lines
originating from different human organs were irradiated by 60Co γ-ray at a total dose of 2
Gy, and the changes associated with EMT, including morphology, EMT markers, migration
and invasion, were observed by microscope, Western blot, immunofluorescence, scratch …