[HTML][HTML] SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers
Congenital infection of SARS-CoV-2 appears to be exceptionally rare despite many cases of
COVID-19 during pregnancy. Robust proof of placental infection requires demonstration of
viral localization within placental tissue. Only two of the few cases of possible vertical
transmission have demonstrated placental infection. None have shown placental expression
of the ACE2 or TMPRSS2 protein, both required for viral infection. We examined 19 COVID-
19 exposed placentas for histopathologic findings, and for expression of ACE2, and …
COVID-19 during pregnancy. Robust proof of placental infection requires demonstration of
viral localization within placental tissue. Only two of the few cases of possible vertical
transmission have demonstrated placental infection. None have shown placental expression
of the ACE2 or TMPRSS2 protein, both required for viral infection. We examined 19 COVID-
19 exposed placentas for histopathologic findings, and for expression of ACE2, and …