[CITATION][C] Apoptosis in HIV infection
G Pantaleo, AS Fauci - Nature Medicine, 1995 - nature.com
Nature Medicine, 1995•nature.com
TNP-470, a synthetic inhibitor of angio Page 1 TG 1995 Nature Publishing Group http://www.nature.com/naturemedicine
the authors remove the primary tumours, at the same time treating the mice with TNP-470, a
synthetic inhibitor of angiogenesis. The result is that the apoptotic fraction remains high
within the lung micrometastases, and these tumours do not grow. OED. Holmgren et al.
argue two possible explanations for their results. The first is that the primary tumours produce
negative regulators, which inhibit neovascularization of the secondary growths and restrict …
the authors remove the primary tumours, at the same time treating the mice with TNP-470, a
synthetic inhibitor of angiogenesis. The result is that the apoptotic fraction remains high
within the lung micrometastases, and these tumours do not grow. OED. Holmgren et al.
argue two possible explanations for their results. The first is that the primary tumours produce
negative regulators, which inhibit neovascularization of the secondary growths and restrict …
It is reported that DNA fragmentation (indicating apoptosis) is rarely observed in HIV-1 or SIV-producing infected cells, and HIV-1 or SIV RNA is rarely (0-1%) observed in apoptotic cells. What is the role of apoptosis in the pathogenicity of HIV infection? (pages 129–134)
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