[HTML][HTML] Alternative endocytic pathway for immunoglobulin A Fc receptors (CD89) depends on the lack of FcRγ association and protects against degradation of bound …
P Launay, C Patry, A Lehuen, B Pasquier… - Journal of Biological …, 1999 - ASBMB
IgA is the most abundant immunoglobulin in mucosal areas but is only the second most
common antibody isotype in serum because it is catabolized faster than IgG. IgA exists in
monomeric and polymeric forms that function through receptors expressed on effector cells.
Here, we show that IgA Fc receptor (s)(FcαR) are expressed with or without the γ chain on
monocytes and neutrophils. γ-less FcαR represent a significant fraction of surface FcαR
molecules even on cells overexpressing the γ chain. The FcαR-γ2 association is up …
common antibody isotype in serum because it is catabolized faster than IgG. IgA exists in
monomeric and polymeric forms that function through receptors expressed on effector cells.
Here, we show that IgA Fc receptor (s)(FcαR) are expressed with or without the γ chain on
monocytes and neutrophils. γ-less FcαR represent a significant fraction of surface FcαR
molecules even on cells overexpressing the γ chain. The FcαR-γ2 association is up …