Non-alcoholic fatty liver disease (NAFLD) and its complications are an expanding health
problem associated with the metabolic syndrome. Liver sinusoidal endothelial cells (LSECs)
are highly specialized endothelial cells localized at the interface between the blood derived
from the gut and the adipose tissue on the one side, and other liver cells on the other side. In
physiological conditions, LSECs are gatekeepers of liver homeostasis. LSECs display anti-
inflammatory and anti-fibrogenic properties by preventing Kupffer cell and hepatic stellate …