Liver macrophages attract increasing interest due to their crucial roles in homeostasis and
hepatic diseases. Recent findings in mice and man suggest a remarkable phenotypic and
functional diversity of liver macrophages. Kupffer cells, the subset of tissue resident
macrophages with sentinel functions in liver, mainly arise from embryogenic precursors,
whereas in injury, liver tissue is engrafted by monocyte-derived macrophages. Both principal
macrophage populations respond to local or systemic signals and have substantial effects …