Matrix metalloproteinase inhibitors as investigational and therapeutic tools in unrestrained tissue remodeling and pathological disorders
J Liu, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Matrix metalloproteinases (MMPs) are zinc-dependent proteolytic enzymes that degrade
various proteins in the extracellular matrix (ECM). MMPs may also regulate the activity of
membrane receptors and postreceptor signaling mechanisms and thereby affect cell
function. The MMP family includes collagenases, gelatinases, stromelysins, matrilysins,
membrane-type MMPs, and other MMPs. Inactive proMMPs are cleaved by other MMPs or
proteases into active MMPs, which interact with various protein substrates in ECM and cell …
various proteins in the extracellular matrix (ECM). MMPs may also regulate the activity of
membrane receptors and postreceptor signaling mechanisms and thereby affect cell
function. The MMP family includes collagenases, gelatinases, stromelysins, matrilysins,
membrane-type MMPs, and other MMPs. Inactive proMMPs are cleaved by other MMPs or
proteases into active MMPs, which interact with various protein substrates in ECM and cell …