[HTML][HTML] Doxycycline inhibits polarization of macrophages to the proangiogenic M2-type and subsequent neovascularization
L He, AG Marneros - Journal of Biological Chemistry, 2014 - ASBMB
Macrophages occur along a continuum of functional states between M1-type polarized
macrophages with antiangiogenic and antitumor activity and M2-type polarized
macrophages, which have been implicated to promote angiogenesis and tumor growth.
Proangiogenic M2-type macrophages promote various pathologic conditions, including
choroidal neovascularization in models of neovascular age-related macular degeneration,
or certain cancers, such as glioblastoma multiforme. Thus, a potential novel therapeutic …
macrophages with antiangiogenic and antitumor activity and M2-type polarized
macrophages, which have been implicated to promote angiogenesis and tumor growth.
Proangiogenic M2-type macrophages promote various pathologic conditions, including
choroidal neovascularization in models of neovascular age-related macular degeneration,
or certain cancers, such as glioblastoma multiforme. Thus, a potential novel therapeutic …