[HTML][HTML] Wolbachia lipoprotein stimulates innate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis
JD Turner, RS Langley, KL Johnston, K Gentil… - Journal of Biological …, 2009 - ASBMB
Wolbachia endosymbiotic bacteria have been implicated in the inflammatory pathogenesis
of filariasis. Inflammation induced by Brugia malayi female worm extract (BMFE) is
dependent on Toll-like receptors 2 and 6 (TLR2/6) with only a partial requirement for TLR1.
Removal of Wolbachia, lipids, or proteins eliminates all inflammatory activity. Wolbachia
bacteria contain the lipoprotein biosynthesis genes Ltg and LspA but not Lnt, suggesting
Wolbachia proteins cannot be triacylated, accounting for recognition by TLR2/6. Lipoprotein …
of filariasis. Inflammation induced by Brugia malayi female worm extract (BMFE) is
dependent on Toll-like receptors 2 and 6 (TLR2/6) with only a partial requirement for TLR1.
Removal of Wolbachia, lipids, or proteins eliminates all inflammatory activity. Wolbachia
bacteria contain the lipoprotein biosynthesis genes Ltg and LspA but not Lnt, suggesting
Wolbachia proteins cannot be triacylated, accounting for recognition by TLR2/6. Lipoprotein …