[HTML][HTML] The adult murine heart has a sparse, phagocytically active macrophage population that expands through monocyte recruitment and adopts an 'M2'phenotype …
KJ Mylonas, SJ Jenkins, RFP Castellan, D Ruckerl… - Immunobiology, 2015 - Elsevier
Tissue resident macrophages have vital homeostatic roles in many tissues but their roles are
less well defined in the heart. The present study aimed to identify the density, polarisation
status and distribution of macrophages in the healthy murine heart and to investigate their
ability to respond to immune challenge. Histological analysis of hearts from CSF-1 receptor
(csf1-GFP; MacGreen) and CX 3 CR1 (Cx3cr1 GFP/+) reporter mice revealed a sparse
population of GFP positive macrophages that were evenly distributed throughout the left and …
less well defined in the heart. The present study aimed to identify the density, polarisation
status and distribution of macrophages in the healthy murine heart and to investigate their
ability to respond to immune challenge. Histological analysis of hearts from CSF-1 receptor
(csf1-GFP; MacGreen) and CX 3 CR1 (Cx3cr1 GFP/+) reporter mice revealed a sparse
population of GFP positive macrophages that were evenly distributed throughout the left and …