Lymphedema is a localized form of tissue swelling resulting from excessive retention of
lymphatic fluid in the interstitial compartment and caused by impaired lymphatic drainage.
Lymphedema is classified as primary or secondary. Primary lymphedema is caused by
developmental lymphatic vascular anomalies. Secondary lymphedema is acquired and
arises as a result of an underlying systemic disease, trauma, or surgery. We performed
PubMed and Google Scholar searches of the English-language literature (1966-2017) using …