Cytokine-mediated dysregulation of zonula occludens-1 properties in human brain microvascular endothelium
KD Rochfort, PM Cummins - Microvascular research, 2015 - Elsevier
Abstract Zonula occludens-1 (ZO-1) is essential to the proper assembly of interendothelial
junction complexes that control blood–brain barrier (BBB) integrity. The goal of the current
paper was to improve our understanding of how proinflammatory cytokines modulate ZO-1
properties within the human BBB microvascular endothelium. In this respect, we investigated
the effects of TNF-α and IL-6 on ZO-1 using human brain microvascular endothelial cells
(HBMvECs). Following treatment of HBMvECs with either cytokine (0–100 ng/ml, 18 h), we …
junction complexes that control blood–brain barrier (BBB) integrity. The goal of the current
paper was to improve our understanding of how proinflammatory cytokines modulate ZO-1
properties within the human BBB microvascular endothelium. In this respect, we investigated
the effects of TNF-α and IL-6 on ZO-1 using human brain microvascular endothelial cells
(HBMvECs). Following treatment of HBMvECs with either cytokine (0–100 ng/ml, 18 h), we …