Markedly elevated soluble intercellular adhesion molecule 1, soluble vascular cell adhesion molecule 1 levels, and blood-brain barrier breakdown in neuromyelitis …

A Uzawa, M Mori, S Masuda… - Archives of Neurology, 2011 - jamanetwork.com
Objective To evaluate the degree of blood-brain barrier disruption in patients with
neuromyelitis optica (NMO) and to clarify whether the levels of soluble intercellular adhesion
molecule 1 (sICAM-1) and soluble vascular cell adhesion molecule 1 (sVCAM-1) in patients
with NMO can be useful biomarkers for blood-brain barrier breakdown. Design Descriptive
historical cohort. Setting Department of Neurology, Graduate School of Medicine, Chiba
University. Patients The levels of sICAM-1 and sVCAM-1 in 25 patients with NMO, 21 …