[HTML][HTML] Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities
B Razani, JA Engelman, XB Wang, W Schubert… - Journal of Biological …, 2001 - ASBMB
Caveolin-1 is the principal structural protein of caveolae membranes in fibroblasts and
endothelia. Recently, we have shown that the human CAV-1 gene is localized to a
suspected tumor suppressor locus, and mutations in Cav-1 have been implicated in human
cancer. Here, we created a caveolin-1 null (CAV-1−/−) mouse model, using standard
homologous recombination techniques, to assess the role of caveolin-1 in caveolae
biogenesis, endocytosis, cell proliferation, and endothelial nitric-oxide synthase (eNOS) …
endothelia. Recently, we have shown that the human CAV-1 gene is localized to a
suspected tumor suppressor locus, and mutations in Cav-1 have been implicated in human
cancer. Here, we created a caveolin-1 null (CAV-1−/−) mouse model, using standard
homologous recombination techniques, to assess the role of caveolin-1 in caveolae
biogenesis, endocytosis, cell proliferation, and endothelial nitric-oxide synthase (eNOS) …