Progression of acute-to-chronic atopic dermatitis is associated with quantitative rather than qualitative changes in cytokine responses
Background Although multiple studies have assessed molecular changes in chronic atopic
dermatitis (AD) lesions, little is known about the transition from acute to chronic disease
stages, and the factors and mechanisms that shape chronic inflammatory activity. Objectives
We sought to assess the global transcriptome changes that characterize the progression
from acute to chronic stages of AD. Methods We analyzed transcriptome changes in paired
nonlesional skin, acute and chronic AD lesions from 11 patients and 38 healthy controls by …
dermatitis (AD) lesions, little is known about the transition from acute to chronic disease
stages, and the factors and mechanisms that shape chronic inflammatory activity. Objectives
We sought to assess the global transcriptome changes that characterize the progression
from acute to chronic stages of AD. Methods We analyzed transcriptome changes in paired
nonlesional skin, acute and chronic AD lesions from 11 patients and 38 healthy controls by …