[HTML][HTML] Intestinal bacteria induce TSLP to promote mutualistic T-cell responses

I Mosconi, MB Geuking, MM Zaiss, JC Massacand… - Mucosal …, 2013 - Elsevier
Thymic stromal lymphopoietin (TSLP) is constitutively expressed in the intestine and is
known to regulate inflammation in models of colitis. We show that steady-state TSLP
expression requires intestinal bacteria and has an important role in limiting the expansion of
colonic T helper type 17 (Th17) cells. Inappropriate expansion of the colonic Th17 cells
occurred in response to an entirely benign intestinal microbiota, as determined following the
colonization of germ-free C57BL/6 or TSLPR−/− mice with the altered Schaedler flora (ASF) …