[HTML][HTML] Central role of mitofusin 2 in autophagosome-lysosome fusion in cardiomyocytes

T Zhao, X Huang, L Han, X Wang, H Cheng… - Journal of Biological …, 2012 - ASBMB
In the heart, autophagy has been implicated in cardioprotection and ischemia-reperfusion
tolerance, and the dysregulation of autophagy is associated with the development of heart
failure. Mitochondrial dynamic proteins are profoundly involved in autophagic processes,
especially the initiation and formation of autophagosomes, but it is not clear whether they
play any role in cardiac autophagy. We previously reported that mitofusin 2 (MFN2), a
mitochondrial outer membrane protein, serves as a major determinant of cardiomyocyte …