[HTML][HTML] Mutated major histocompatibility complex class II transactivator up-regulates interleukin-33-dependent differentiation of Th2 subset through Nod2 binding for …
Z Yang, P Gu, X Shao, Z Li, Y Zhou, L Lu… - Journal of Biological …, 2012 - ASBMB
Dominant-negative mutants of class II transactivator (mCIITAs) with N-terminal depletion
have been used to repress the transcription of class II genes in xenotransplantation. Here,
we report that mCIITA overexpressing myeloid cell line Ana-1 (Ana-1-mCIITA) derived from a
C57BL/6 mouse was able to down-regulate the MHC class II expression and reverse
immune responses from Th1 (IL-2+ IFN-γ+ STAT4+) to Th2 (IL-4+ IL-5+ IL-10+ IL-13+
STAT6+) when cocultured with T cells. Mechanism analysis indicated that the mCIITA …
have been used to repress the transcription of class II genes in xenotransplantation. Here,
we report that mCIITA overexpressing myeloid cell line Ana-1 (Ana-1-mCIITA) derived from a
C57BL/6 mouse was able to down-regulate the MHC class II expression and reverse
immune responses from Th1 (IL-2+ IFN-γ+ STAT4+) to Th2 (IL-4+ IL-5+ IL-10+ IL-13+
STAT6+) when cocultured with T cells. Mechanism analysis indicated that the mCIITA …