Indomethacin and the nephrotic syndrome
IH Shehadeh, LM Demers, AB Abt, AC Schoolwerth - JAMA, 1979 - jamanetwork.com
Treatment of membranous nephropathy and the nephrotic syndrome with 2 mg/kg/day of
indomethacin resulted in prompt and sustained reduction in urinary protein excretion and
the loss of edema fluid, which allowed the withdrawal of diuretic therapy and liberalization of
salt intake. The reduction in proteinuria was paralleled by a decrease in urinary
prostaglandin E (PGE) and F (PGF) levels. Plasma PGE and PGF levels did not change
appreciably. Withdrawal of indomethacin therapy resulted in an increase in urinary protein …
indomethacin resulted in prompt and sustained reduction in urinary protein excretion and
the loss of edema fluid, which allowed the withdrawal of diuretic therapy and liberalization of
salt intake. The reduction in proteinuria was paralleled by a decrease in urinary
prostaglandin E (PGE) and F (PGF) levels. Plasma PGE and PGF levels did not change
appreciably. Withdrawal of indomethacin therapy resulted in an increase in urinary protein …