Recent advances in genome editing technologies such as the clustered regularly
interspaced short palindromic repeats (CRISPR)-associated endonuclease Cas9 have
enabled the rapid and efficient modification of endogenous genomes in a variety of cell
types, accelerating biomedical research. In particular, precise genome editing in somatic
cells in vivo allows for the rapid generation of genetically modified cells in living animals and
holds great promise for the possibility of directly correcting genetic defects associated with …