[PDF][PDF] Human T cell development, localization, and function throughout life

BV Kumar, TJ Connors, DL Farber - Immunity, 2018 - cell.com
BV Kumar, TJ Connors, DL Farber
Immunity, 2018cell.com
Throughout life, T cells coordinate multiple aspects of adaptive immunity, including
responses to pathogens, allergens, and tumors. In mouse models, the role of T cells is
studied in the context of a specific type of pathogen, antigen, or disease condition over a
limited time frame, whereas in humans, T cells control multiple insults simultaneously
throughout the body and maintain immune homeostasis over decades. In this review, we
discuss how human T cells develop and provide essential immune protection at different life …
Throughout life, T cells coordinate multiple aspects of adaptive immunity, including responses to pathogens, allergens, and tumors. In mouse models, the role of T cells is studied in the context of a specific type of pathogen, antigen, or disease condition over a limited time frame, whereas in humans, T cells control multiple insults simultaneously throughout the body and maintain immune homeostasis over decades. In this review, we discuss how human T cells develop and provide essential immune protection at different life stages and highlight tissue localization and subset delineation as key determinants of the T cell functional role in immune responses. We also discuss how anatomic compartments undergo distinct age-associated changes in T cell subset composition and function over a lifetime. It is important to consider age and tissue influences on human T cells when developing targeted strategies to modulate T cell-mediated immunity in vaccines and immunotherapies.
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