[HTML][HTML] Receptor activator of nuclear factor κB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss
Production of the cytokine receptor activator of NFκB ligand (RANKL) by lymphocytes has
been proposed as a mechanism by which sex steroid deficiency causes bone loss.
However, there have been no studies that functionally link RANKL expression in
lymphocytes with bone loss in this condition. Herein, we examined whether RANKL
expression in either B or T lymphocytes contributes to ovariectomy-induced bone loss in
mice. Mice harboring a conditional RANKL allele were crossed with CD19-Cre or Lck-Cre …
been proposed as a mechanism by which sex steroid deficiency causes bone loss.
However, there have been no studies that functionally link RANKL expression in
lymphocytes with bone loss in this condition. Herein, we examined whether RANKL
expression in either B or T lymphocytes contributes to ovariectomy-induced bone loss in
mice. Mice harboring a conditional RANKL allele were crossed with CD19-Cre or Lck-Cre …