Complement in IgA nephropathy: the role of complement in the pathogenesis, diagnosis, and future management of IgA nephropathy
NR Medjeral-Thomas, MM O'Shaughnessy - Advances in Chronic Kidney …, 2020 - Elsevier
Immunoglobulin A (IgA) nephropathy (IgAN) is an important cause of chronic and end-stage
kidney disease. IgAN pathogenesis is incompletely understood. In particular, we cannot
adequately explain the heterogeneity in clinical and histologic features and severities that
characterizes IgAN. This limits patient stratification to appropriate and effective treatments
and the development of disease-targeted therapies. Studies of the role of the alternative,
lectin, and terminal complement pathways in IgAN have enhanced our understanding of …
kidney disease. IgAN pathogenesis is incompletely understood. In particular, we cannot
adequately explain the heterogeneity in clinical and histologic features and severities that
characterizes IgAN. This limits patient stratification to appropriate and effective treatments
and the development of disease-targeted therapies. Studies of the role of the alternative,
lectin, and terminal complement pathways in IgAN have enhanced our understanding of …