Aberrant glycosylation of the IgA1 molecule in IgA nephropathy
J Novak, J Barratt, BA Julian, MB Renfrow - Seminars in nephrology, 2018 - Elsevier
IgA nephropathy, the most common primary glomerulonephritis in the world and a frequent
cause of end-stage renal disease, is characterized by typical mesangial deposits of IgA1, as
described by Berger and Hinglaise in 1968. Since then, it has been discovered that aberrant
IgA1 O-glycosylation is involved in disease pathogenesis. Progress in glycomic, genomic,
clinical, analytical, and biochemical studies has shown autoimmune features of IgA
nephropathy. The autoimmune character of the disease is explained by a multihit …
cause of end-stage renal disease, is characterized by typical mesangial deposits of IgA1, as
described by Berger and Hinglaise in 1968. Since then, it has been discovered that aberrant
IgA1 O-glycosylation is involved in disease pathogenesis. Progress in glycomic, genomic,
clinical, analytical, and biochemical studies has shown autoimmune features of IgA
nephropathy. The autoimmune character of the disease is explained by a multihit …