Steroid levels in cancer of the prostate-markers of tumour differentiation and adequacy of anti-androgen therapy
J Geller, J Albert, D Loza - Journal of steroid Biochemistry, 1979 - Elsevier
Dihydrotestosterone (DHT) has been shown to be the major biologically active androgen in
the prostate; its steady state level depends upon plasma-testosterone substrate, 5α-
reductase, 3-oxidoreductase and receptor binding, all essential biochemical steps for the
mediation of androgen action. In both treated and untreated patients with prostate cancer,
we have studied the usefulness of tissue DHT levels as (1) biochemical markers of tumour
differentiation and (2) indicators of adequacy of antiandrogen therapy. Average DHT in 29 …
the prostate; its steady state level depends upon plasma-testosterone substrate, 5α-
reductase, 3-oxidoreductase and receptor binding, all essential biochemical steps for the
mediation of androgen action. In both treated and untreated patients with prostate cancer,
we have studied the usefulness of tissue DHT levels as (1) biochemical markers of tumour
differentiation and (2) indicators of adequacy of antiandrogen therapy. Average DHT in 29 …