Gastrointestinal symptoms in Parkinson's disease

LL Edwards, RF Pfeiffer, EMM Quigley… - … : official journal of the …, 1991 - Wiley Online Library
LL Edwards, RF Pfeiffer, EMM Quigley, R Hofman, M Balluff
Movement disorders: official journal of the Movement Disorder Society, 1991Wiley Online Library
We have investigated the prevalence of gastrointestinal (GI) symptoms in 98 individuals with
Parkinson's disease (PD) and in a control group of 50. Seventy‐nine of those with PD were
being treated with dopaminergic medications and 19 were untreated. Those symptoms
occurring more frequently in PD patients than in controls included abnormal salivation,
dysphagia, nausea, constipation, and defecatory dysfunction. Except for defecatory
dysfunction, symptoms did not correlate with treatment but instead correlated with disease …
Abstract
We have investigated the prevalence of gastrointestinal (GI) symptoms in 98 individuals with Parkinson's disease (PD) and in a control group of 50. Seventy‐nine of those with PD were being treated with dopaminergic medications and 19 were untreated. Those symptoms occurring more frequently in PD patients than in controls included abnormal salivation, dysphagia, nausea, constipation, and defecatory dysfunction. Except for defecatory dysfunction, symptoms did not correlate with treatment but instead correlated with disease severity. This suggests that the GI symptoms of PD reflect direct involvement in the GI tract by the primary disease process.
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